Journal: Multiple sclerosis and related disorders

Article Title: The impact of socioeconomic status on subsequent neurological outcomes in multiple sclerosis

doi: 10.1016/j.msard.2022.103994

Figure Lengend Snippet: American Community Survey data from 2011–2015 (referred as 2015) provided neighborhood socioeconomic status as the exposure. Patient-reported outcomes (MSRS-R, PDDS, PROMIS-physical function) surveyed during the most recent year between 2018 and 2020 provided the clinically relevant neurological and physical functional assessment. CUIMC, Columbia University Irving Medical Center. PROMOTE, Prospective Investigation of Multiple Sclerosis in the Three Rivers Region. This figure was created with BioRender.com.

Article Snippet: Estimate 1 95% CI 2 P-Value 3 N 4 Neighborhood Median Household Income MSRS-R −3.80e-05 −5.05e-05, −2.56e-05 <0.001 1665 PDDS −8.58e-06 −1.28e-05, −4.32e-06 <0.001 1646 PROMIS 2.55e-05 5.96e-07, 5.05e-05 0.044 1020 Neighborhood Median Home Value MSRS-R −6.50e-06 −8.16e-06, −4.84e-06 <0.001 1666 PDDS −1.54e-06 −2.11e-06, −9.65e-07 <0.001 1647 PROMIS 4.98e-06 1.81e-06, 8.14e-06 0.00209 1021 Neighborhood Percent with College Education MSRS-R −7.31 −8.99, −5.64 <0.001 1668 PDDS −1.62 −2.20, −1.05 <0.001 1649 PROMIS 9.31 5.73, 12.89 <0.001 1022 Open in a separate window 1.

Techniques: Functional Assay

Journal: Multiple sclerosis and related disorders

Article Title: The impact of socioeconomic status on subsequent neurological outcomes in multiple sclerosis

doi: 10.1016/j.msard.2022.103994

Figure Lengend Snippet: Participant characteristics

Article Snippet: Estimate 1 95% CI 2 P-Value 3 N 4 Neighborhood Median Household Income MSRS-R −3.80e-05 −5.05e-05, −2.56e-05 <0.001 1665 PDDS −8.58e-06 −1.28e-05, −4.32e-06 <0.001 1646 PROMIS 2.55e-05 5.96e-07, 5.05e-05 0.044 1020 Neighborhood Median Home Value MSRS-R −6.50e-06 −8.16e-06, −4.84e-06 <0.001 1666 PDDS −1.54e-06 −2.11e-06, −9.65e-07 <0.001 1647 PROMIS 4.98e-06 1.81e-06, 8.14e-06 0.00209 1021 Neighborhood Percent with College Education MSRS-R −7.31 −8.99, −5.64 <0.001 1668 PDDS −1.62 −2.20, −1.05 <0.001 1649 PROMIS 9.31 5.73, 12.89 <0.001 1022 Open in a separate window 1.

Techniques: Biomarker Discovery

Journal: Multiple sclerosis and related disorders

Article Title: The impact of socioeconomic status on subsequent neurological outcomes in multiple sclerosis

doi: 10.1016/j.msard.2022.103994

Figure Lengend Snippet: PROs included MSRS-R median score, PROMIS-physical function median T-scores, and proportion of people with PDDS median score dichotomized according to full-time requirement for ambulation assistance versus otherwise (PDDS≥4 versus <4), all from the latest year between 2018 and 2020.

Article Snippet: Estimate 1 95% CI 2 P-Value 3 N 4 Neighborhood Median Household Income MSRS-R −3.80e-05 −5.05e-05, −2.56e-05 <0.001 1665 PDDS −8.58e-06 −1.28e-05, −4.32e-06 <0.001 1646 PROMIS 2.55e-05 5.96e-07, 5.05e-05 0.044 1020 Neighborhood Median Home Value MSRS-R −6.50e-06 −8.16e-06, −4.84e-06 <0.001 1666 PDDS −1.54e-06 −2.11e-06, −9.65e-07 <0.001 1647 PROMIS 4.98e-06 1.81e-06, 8.14e-06 0.00209 1021 Neighborhood Percent with College Education MSRS-R −7.31 −8.99, −5.64 <0.001 1668 PDDS −1.62 −2.20, −1.05 <0.001 1649 PROMIS 9.31 5.73, 12.89 <0.001 1022 Open in a separate window 1.

Techniques:

Journal: Multiple sclerosis and related disorders

Article Title: The impact of socioeconomic status on subsequent neurological outcomes in multiple sclerosis

doi: 10.1016/j.msard.2022.103994

Figure Lengend Snippet: Covariate-adjusted regression analysis using area deprivation index in 2015 as the exposure and the median scores of patient-reported outcomes of neurological and physical function from the latest year between 2018 and 2020.

Article Snippet: Estimate 1 95% CI 2 P-Value 3 N 4 Neighborhood Median Household Income MSRS-R −3.80e-05 −5.05e-05, −2.56e-05 <0.001 1665 PDDS −8.58e-06 −1.28e-05, −4.32e-06 <0.001 1646 PROMIS 2.55e-05 5.96e-07, 5.05e-05 0.044 1020 Neighborhood Median Home Value MSRS-R −6.50e-06 −8.16e-06, −4.84e-06 <0.001 1666 PDDS −1.54e-06 −2.11e-06, −9.65e-07 <0.001 1647 PROMIS 4.98e-06 1.81e-06, 8.14e-06 0.00209 1021 Neighborhood Percent with College Education MSRS-R −7.31 −8.99, −5.64 <0.001 1668 PDDS −1.62 −2.20, −1.05 <0.001 1649 PROMIS 9.31 5.73, 12.89 <0.001 1022 Open in a separate window 1.

Techniques:

Journal: Multiple sclerosis and related disorders

Article Title: The impact of socioeconomic status on subsequent neurological outcomes in multiple sclerosis

doi: 10.1016/j.msard.2022.103994

Figure Lengend Snippet: Area deprivation index in 2015 was the exposure for the median scores of the patient-reported outcomes of neurological and physical function from the latest year between 2018 and 2020. Higher scores of MS symptom burden (MSRS-R), higher scores of gait impairment (PDDS) and lower T-scores of PROMIS-physical function indicated greater neurological and/or physical disability. Each square was the standardized β coefficient, and each line was the 95% confidence interval (95%-CI). The diamond represented the meta-analyzed β coefficient and 95% CI in a random-effects meta-analysis of the two cohorts. Higher ADI was associated with subsequently greater MSRS-R and PDDS. The significance threshold for multiple testing was p=0.0167.

Article Snippet: Estimate 1 95% CI 2 P-Value 3 N 4 Neighborhood Median Household Income MSRS-R −3.80e-05 −5.05e-05, −2.56e-05 <0.001 1665 PDDS −8.58e-06 −1.28e-05, −4.32e-06 <0.001 1646 PROMIS 2.55e-05 5.96e-07, 5.05e-05 0.044 1020 Neighborhood Median Home Value MSRS-R −6.50e-06 −8.16e-06, −4.84e-06 <0.001 1666 PDDS −1.54e-06 −2.11e-06, −9.65e-07 <0.001 1647 PROMIS 4.98e-06 1.81e-06, 8.14e-06 0.00209 1021 Neighborhood Percent with College Education MSRS-R −7.31 −8.99, −5.64 <0.001 1668 PDDS −1.62 −2.20, −1.05 <0.001 1649 PROMIS 9.31 5.73, 12.89 <0.001 1022 Open in a separate window 1.

Techniques:

Journal: Multiple sclerosis and related disorders

Article Title: The impact of socioeconomic status on subsequent neurological outcomes in multiple sclerosis

doi: 10.1016/j.msard.2022.103994

Figure Lengend Snippet: The significant ADI components in 2015 included neighborhood median household income (A-C), neighborhood median home value (D-F), and neighborhood percent with college education (G-I) within the zip code of a participant’s residential address. The PROs included the median scores of MSRS-R, PDDS, and PROMIS-physical function from the latest year between 2018 and 2020.

Article Snippet: Estimate 1 95% CI 2 P-Value 3 N 4 Neighborhood Median Household Income MSRS-R −3.80e-05 −5.05e-05, −2.56e-05 <0.001 1665 PDDS −8.58e-06 −1.28e-05, −4.32e-06 <0.001 1646 PROMIS 2.55e-05 5.96e-07, 5.05e-05 0.044 1020 Neighborhood Median Home Value MSRS-R −6.50e-06 −8.16e-06, −4.84e-06 <0.001 1666 PDDS −1.54e-06 −2.11e-06, −9.65e-07 <0.001 1647 PROMIS 4.98e-06 1.81e-06, 8.14e-06 0.00209 1021 Neighborhood Percent with College Education MSRS-R −7.31 −8.99, −5.64 <0.001 1668 PDDS −1.62 −2.20, −1.05 <0.001 1649 PROMIS 9.31 5.73, 12.89 <0.001 1022 Open in a separate window 1.

Techniques:

Journal: Multiple sclerosis and related disorders

Article Title: The impact of socioeconomic status on subsequent neurological outcomes in multiple sclerosis

doi: 10.1016/j.msard.2022.103994

Figure Lengend Snippet: Covariate-adjusted regression analysis of individual driving components of the area deprivation index (ADI) in 2015 as the exposure and median scores of patient-reported outcomes of neurological function from the latest year between 2018 and 2020 from the joint cohorts.

Article Snippet: Estimate 1 95% CI 2 P-Value 3 N 4 Neighborhood Median Household Income MSRS-R −3.80e-05 −5.05e-05, −2.56e-05 <0.001 1665 PDDS −8.58e-06 −1.28e-05, −4.32e-06 <0.001 1646 PROMIS 2.55e-05 5.96e-07, 5.05e-05 0.044 1020 Neighborhood Median Home Value MSRS-R −6.50e-06 −8.16e-06, −4.84e-06 <0.001 1666 PDDS −1.54e-06 −2.11e-06, −9.65e-07 <0.001 1647 PROMIS 4.98e-06 1.81e-06, 8.14e-06 0.00209 1021 Neighborhood Percent with College Education MSRS-R −7.31 −8.99, −5.64 <0.001 1668 PDDS −1.62 −2.20, −1.05 <0.001 1649 PROMIS 9.31 5.73, 12.89 <0.001 1022 Open in a separate window 1.

Techniques:

Journal: Multiple sclerosis and related disorders

Article Title: The impact of socioeconomic status on subsequent neurological outcomes in multiple sclerosis

doi: 10.1016/j.msard.2022.103994

Figure Lengend Snippet: Indirect effects of neighborhood-level health insurance coverage (percent of population with private or Medicaid insurance within the neighborhood of the participant’s home residence) in 2015 on mediating the covariate-adjusted association between area deprivation index in 2015 and the median scores of patient-reported outcomes of neurological and physical function from the latest year between 2018 and 2020 from the joint cohorts.

Article Snippet: Estimate 1 95% CI 2 P-Value 3 N 4 Neighborhood Median Household Income MSRS-R −3.80e-05 −5.05e-05, −2.56e-05 <0.001 1665 PDDS −8.58e-06 −1.28e-05, −4.32e-06 <0.001 1646 PROMIS 2.55e-05 5.96e-07, 5.05e-05 0.044 1020 Neighborhood Median Home Value MSRS-R −6.50e-06 −8.16e-06, −4.84e-06 <0.001 1666 PDDS −1.54e-06 −2.11e-06, −9.65e-07 <0.001 1647 PROMIS 4.98e-06 1.81e-06, 8.14e-06 0.00209 1021 Neighborhood Percent with College Education MSRS-R −7.31 −8.99, −5.64 <0.001 1668 PDDS −1.62 −2.20, −1.05 <0.001 1649 PROMIS 9.31 5.73, 12.89 <0.001 1022 Open in a separate window 1.

Techniques:

Journal: Multiple sclerosis and related disorders

Article Title: The impact of socioeconomic status on subsequent neurological outcomes in multiple sclerosis

doi: 10.1016/j.msard.2022.103994

Figure Lengend Snippet: Covariate-adjusted regression analysis using nine individual household income brackets ranging from “$0 to $19,999” to “$125,000 or higher” and the patient-reported outcomes of neurological and physical function for each participant in a subgroup analysis of joint cohorts that accounted for the area deprivation index.

Article Snippet: Estimate 1 95% CI 2 P-Value 3 N 4 Neighborhood Median Household Income MSRS-R −3.80e-05 −5.05e-05, −2.56e-05 <0.001 1665 PDDS −8.58e-06 −1.28e-05, −4.32e-06 <0.001 1646 PROMIS 2.55e-05 5.96e-07, 5.05e-05 0.044 1020 Neighborhood Median Home Value MSRS-R −6.50e-06 −8.16e-06, −4.84e-06 <0.001 1666 PDDS −1.54e-06 −2.11e-06, −9.65e-07 <0.001 1647 PROMIS 4.98e-06 1.81e-06, 8.14e-06 0.00209 1021 Neighborhood Percent with College Education MSRS-R −7.31 −8.99, −5.64 <0.001 1668 PDDS −1.62 −2.20, −1.05 <0.001 1649 PROMIS 9.31 5.73, 12.89 <0.001 1022 Open in a separate window 1.

Techniques: